Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic
Identifieur interne : 000404 ( Main/Exploration ); précédent : 000403; suivant : 000405Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic
Auteurs : Andrew B. WestSource :
- Movement Disorders [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Protein-Serine-Threonine Kinases.
- chemical , genetics : Protein-Serine-Threonine Kinases.
- chemical , metabolism : Protein-Serine-Threonine Kinases.
- chemical , therapeutic use : Neuroprotective Agents.
- drug therapy : Parkinson Disease.
- genetics : Mutation, Parkinson Disease.
- Animals, Humans.
Abstract
The burden that Parkinson's disease (PD) exacts on the population continues to increase year after year. Though refinement of symptomatic treatments continues at a reasonable pace, no accepted therapies are available to slow or prevent disease progression. The
Url:
DOI: 10.1002/mds.26075
PubMed: 25448543
PubMed Central: 4318704
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic</title><author><name sortKey="West, Andrew B" sort="West, Andrew B" uniqKey="West A" first="Andrew B" last="West">Andrew B. West</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25448543</idno><idno type="pmc">4318704</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318704</idno><idno type="RBID">PMC:4318704</idno><idno type="doi">10.1002/mds.26075</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000444</idno><idno type="wicri:Area/Pmc/Curation">000444</idno><idno type="wicri:Area/Pmc/Checkpoint">000010</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000339</idno><idno type="wicri:Area/PubMed/Curation">000339</idno><idno type="wicri:Area/PubMed/Checkpoint">000046</idno><idno type="wicri:Area/Ncbi/Merge">004170</idno><idno type="wicri:Area/Ncbi/Curation">004170</idno><idno type="wicri:Area/Ncbi/Checkpoint">004170</idno><idno type="wicri:doubleKey">0885-3185:2014:West A:ten:years:and</idno><idno type="wicri:Area/Main/Merge">000404</idno><idno type="wicri:Area/Main/Curation">000404</idno><idno type="wicri:Area/Main/Exploration">000404</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic</title><author><name sortKey="West, Andrew B" sort="West, Andrew B" uniqKey="West A" first="Andrew B" last="West">Andrew B. West</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mutation (genetics)</term><term>Neuroprotective Agents (therapeutic use)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (genetics)</term><term>Protein-Serine-Threonine Kinases (antagonists & inhibitors)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Protein-Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The burden that Parkinson's disease (PD) exacts on the population continues to increase year after year. Though refinement of symptomatic treatments continues at a reasonable pace, no accepted therapies are available to slow or prevent disease progression. The <italic>leucine-rich repeat kinase 2</italic> (<italic>LRRK2</italic>) gene was identified in PD genetic studies and offers new hope for novel therapeutic approaches. The evidence linking LRRK2 kinase activity to PD susceptibility is presented, as well as seminal discoveries relevant to the prosecution of LRRK2 kinase inhibition. Finally, suggestions are made for predictive preclinical modeling and successful first-in-human trials. © 2014 The Authors. <italic>Movement</italic> Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stovall, S" uniqKey="Stovall S">S Stovall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garrison, Hh" uniqKey="Garrison H">HH Garrison</name></author><author><name sortKey="Deschamps, Am" uniqKey="Deschamps A">AM Deschamps</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name></author><author><name sortKey="Mata, If" uniqKey="Mata I">IF Mata</name></author><author><name sortKey="Hulihan, M" uniqKey="Hulihan M">M Hulihan</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Kirik</name></author><author><name sortKey="Rosenblad, C" uniqKey="Rosenblad C">C Rosenblad</name></author><author><name sortKey="Burger, C" uniqKey="Burger C">C Burger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daher, Jp" uniqKey="Daher J">JP Daher</name></author><author><name sortKey="Volpicelli Daley, La" uniqKey="Volpicelli Daley L">LA Volpicelli-Daley</name></author><author><name sortKey="Blackburn, Jp" uniqKey="Blackburn J">JP Blackburn</name></author><author><name sortKey="Moehle, Ms" uniqKey="Moehle M">MS Moehle</name></author><author><name sortKey="West, Ab" uniqKey="West A">AB West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moehle, Ms" uniqKey="Moehle M">MS Moehle</name></author><author><name sortKey="Webber, Pj" uniqKey="Webber P">PJ Webber</name></author><author><name sortKey="Tse, T" uniqKey="Tse T">T Tse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hojjati, Mr" uniqKey="Hojjati M">MR Hojjati</name></author><author><name sortKey="Van Woerden, Gm" uniqKey="Van Woerden G">GM van Woerden</name></author><author><name sortKey="Tyler, Wj" uniqKey="Tyler W">WJ Tyler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baptista, Ma" uniqKey="Baptista M">MA Baptista</name></author><author><name sortKey="Dave, Kd" uniqKey="Dave K">KD Dave</name></author><author><name sortKey="Frasier, Ma" uniqKey="Frasier M">MA Frasier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, P" uniqKey="Morgan P">P Morgan</name></author><author><name sortKey="Van Der Graaf, Ph" uniqKey="Van Der Graaf P">PH Van Der Graaf</name></author><author><name sortKey="Arrowsmith, J" uniqKey="Arrowsmith J">J Arrowsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, Kb" uniqKey="Fraser K">KB Fraser</name></author><author><name sortKey="Moehle, Ms" 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Chakrabarti</name></author><author><name sortKey="Storm, Mv" uniqKey="Storm M">MV Storm</name></author><author><name sortKey="Jain, A" uniqKey="Jain A">A Jain</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="West, Andrew B" sort="West, Andrew B" uniqKey="West A" first="Andrew B" last="West">Andrew B. 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